; China Nicolsamide fale gaosimea ma faʻatau oloa |Taofi

oloa

Nicolsamide papalama

Fa'amatalaga Puupuu:

Tulaga:
O bolus cotnas taitasi e 1250 mg niclosamide
Fa'ailoga:
Mo manu fa'ama'i fa'ama'i, cestodiasis, e pei o povi ma mamoe's moniezia, avitellina centripunctata, ma isi.


Fa'amatalaga Oloa

O le Niclosamide o se salicylanilide chlorinated e mafai ona tu'u tautala, fa'atasi ai ma fa'ama'i fa'ama'i ma fa'alavelave fa'ama'i.I luga o le faʻatonuga tautala, o le niclosamide faʻapitoa faʻaosoina le faʻaleagaina o le androgen receptor (AR) variant V7 (AR-V7) e ala i le proteasome-mediated ala.O lenei mea e faʻaitiitia ai le faʻaalia o le AR variant, faʻalavelaveina le AR-V7-mediated transcriptional activity, ma faʻaititia le AR-V7 faʻafaigaluegaina i le prostate-specific antigen (PSA) gene promoter.E taofia foi e le Niclosamide le AR-V7-mediated STAT3 phosphorylation ma le faʻagaoioia.O lenei mea e taofia ai le faʻailogaina o AR / STAT3 ma taofia le faʻaalia o kenera taulaʻi STAT3.A'o fa'atasi, e ono fa'alavelaveina le fa'atuputeleina o sela o le kanesa e fa'aosoina le AR-V7.O le AR-V7 variant, lea e fa'ailogaina e ala i le so'otaga fa'atasi o AR exons 1/2/3/CE3, e fa'atulafonoina i le tele o ituaiga sela o le kanesa, ma e feso'ota'i ma le alualu i luma o le kanesa ma le tete'e atu i togafitiga fa'atatau AR.

Tulaga:

O bolus cotnas taitasi e 1250 mg niclosamide

Fa'ailoga:

Mo manu fa'ama'i fa'ama'i, cestodiasis, e pei o povi ma mamoe's moniezia, avitellina centripunctata, ma isi.

Fuafuaga ma Fa'aoga:

Tu'u gutu taitasi 1kg le mamafa o le tino.

povi: 40-60mg

Mamoe: 60-70mg

Taimi fa'aui i tua:

Mamoe: 28 aso.

povi:28 aso.

Lapopo'a o le afifi: 5 papa'a i le ma'i, 10 pulu i le pusa


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