O le Niclosamide ose salicylanilide chlorinated e mafai ona tu'u tautala, fa'atasi ai ma fa'ama'i fa'ama'i ma fa'alavelave fa'ama'i. I luga o le faʻatonuga tautala, o le niclosamide faʻapitoa faʻaosoina le faʻaleagaina o le androgen receptor (AR) variant V7 (AR-V7) e ala i le proteasome-mediated ala. O lenei mea e faʻaitiitia ai le faʻaalia o le AR variant, faʻalavelaveina le AR-V7-mediated transcriptional activity, ma faʻaititia le AR-V7 faʻafaigaluegaina i le prostate-specific antigen (PSA) gene promoter. E taofia foi e le Niclosamide le AR-V7-mediated STAT3 phosphorylation ma le faʻagaoioia. O lenei mea e taofia ai le faʻailogaina o AR / STAT3 ma taofia le faʻaalia o kenera taulaʻi STAT3. A'o fa'atasi, e ono fa'alavelaveina le tupu a'e o sela o le kanesa e fa'aosoina le AR-V7. O le AR-V7 ese'ese, lea e fa'ailogaina e ala i le so'otaga fa'atasi o AR exons 1/2/3/CE3, e fa'atulafonoina i le tele o ituaiga sela o le kanesa, ma e feso'ota'i ma le alualu i luma o le kanesa ma le tetee atu i togafitiga fa'atatau i le AR.

Tulaga:

O bolus cotnas taitasi e 1250 mg niclosamide

Fa'ailoga:

Mo manu fa'ama'i fa'ama'i, cestodiasis, e pei o povi ma mamoe's moniezia, avitellina centripunctata, ma isi.

Fuafuaga ma Fa'aoga:

Tu'u gutu taitasi 1kg le mamafa o le tino.

povi: 40-60mg

Mamoe: 60-70mg

Taimi fa'aui i tua:

Mamoe: 28 aso.

povi:28 aso.

Lapo'a o le afifi: 5 papa'a i le ma'i, 10 ta'i i le pusa